While the side effects of etanercept can be serious, it’s not clear if these side effects are likely at the low dosage used for stroke patients. Such events include injection site reactions, reactivation of tuberculosis, reactivation of hepatitis B virus infection, congestive heart failure, demyelinating neurologic disorders, vasculitis, and hematologic disorders such as aplastic anemia and pancytopenia.” Considering the Risk of Etanercept for Use in Stroke “Serious adverse events are described in studies of patients receiving etanercept for other conditions. The AAN stated that the cost of a 25-mg vial of Etanercept is about $440 – which does not include the extra cost of pretreatment evaluation, administration, and follow up. It also cites that the treatment may be associated with adverse outcomes and high cost. The AAN states that there is insufficient evidence to determine the effectiveness of etanercept for post-stroke disability. To further complicate the issue, the American Academy of Neurology (AAN) published a practice advisory in 2016 on the use of etanercept for stroke recovery. AAN Issues Advisory for Etanercept in Post-Stroke Disability Tobinik was involved in the only clinical trials (one in 20) currently conducted on Etanercept for stroke.Įventually, the American Academy of Neurology (AAN) caught wind of this and issued a warning. The only person currently offering – and therefore profiting – from Etanercept for stroke recovery is Dr. It was once reported that a patient paid $4,800 out-of-pocket for a single treatment of Etanercept and follow-up visit. Potential Bias of Etanercept in Stroke Rehabilitation These results are overwhelmingly positive – and it could be biased. In a non-randomized study of 617 patients, more than 80% of participants saw a reduction in spasticity and more than 85% saw improved movement. There have been eye-witness reports of a single dose of perispinal Etanercept producing an immediately improvement in expressive aphasia, speech apraxia, cognitive function, and left hemiparesis. Researchers are questioning whether or not Etanercept can help reduce that inflammation – and if that will have any effect on post-stroke disability.įor the treatment of stroke, Etanercept is injected into the spine (perispinal etanercept) and the patient is tipped backwards to encourage the drug to enter the brain. This is interesting because it’s theorized that stroke may lead to a persistent neuroinflammatory response in the brain. While stroke is not an autoimmune disease, researchers are exploring whether TNF inhibitors can help post-stroke disability by reducing inflammation in the brain. So why are we starting now? Using Etanercept with Stroke Patients This shows that Etanercept is not conventionally used in stroke recovery. Stroke is not mentioned in any of the literature on Etanercept. Right now, Etanercept is used to treat autoimmune diseases like rheumatoid arthritis and psoriasis. Etanercept interferes with TNF to discourage the body from producing this inflammatory response.Įtanercept is intended to fight inflammation in people with autoimmune diseases where inflammation is known to cause problems. Tumor necrosis factor (TNF) encourages inflammation in the body, which is needed to fight disease and infection. What Is Etanercept?Įtanercept (Enbrel) is a drug that’s a tumor necrosis factor inhibitor that alters your body’s inflammation response. Here’s everything you need to know about Etanercept injections for stroke recovery. If you’re considering this costly treatment, it’s important to know the facts before making a decision. The success stories seem promising – but the non-randomized controlled clinical trials could be biased and the American Academy of Neurology has even issued a warning. The Etanercept injection for stroke patients is causing controversy.
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